TOW the trials

Magpie:

multicentre RCT 10000 women

mag sulph vs placebo

primary outcomes: eclampsia and death of baby

result: 58% lower risk of eclampsia, lower maternal mortality, no diff in baby mortality

TRACman

tracheostomy : early vs late

multicentre prospective RCT

early 1-4, late not before day 10

primary outcome : 30day mortality

CESAR trial:

conventional ventilatory support vs ECMO in severe adult respi failure

mortality and disability lower in ECMO group , likely to be cost effective

VASST trial

vasopressin and septic shock:

low dose 0.01-0.03u/min or norad

NO in ARDS:

no sig diff in groups in mortality, duration, ventilator free days

no group: higher pao2/fio2 on day 1, but increased risk of renal dysfunciton